diff --git a/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfiler.h b/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfiler.h
index 2248474820..3fedc99566 100644
--- a/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfiler.h
+++ b/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfiler.h
@@ -30,6 +30,12 @@ namespace AZ
                 
                 const char* const m_groupName = nullptr;
                 const char* const m_regionName = nullptr;
+
+                struct Hash
+                {
+                    AZStd::size_t operator()(const GroupRegionName& name) const;
+                };
+                bool operator==(const GroupRegionName& other) const;
             };
 
             CachedTimeRegion() = default;
@@ -95,6 +101,9 @@ namespace AZ
             virtual void SetProfilerEnabled(bool enabled) = 0;
 
             virtual bool IsProfilerEnabled() const = 0 ;
+
+            //! Used by AZ_ATOM_PROFILE_DYNAMIC to create GroupRegionNames with known lifetimes.
+            virtual const CachedTimeRegion::GroupRegionName& InsertDynamicName(const char* groupName, const AZStd::string& regionName) = 0;
         };
 
     } // namespace RPI
@@ -120,3 +129,10 @@ namespace AZ
 #define AZ_ATOM_PROFILE_FUNCTION(groupName, regionName) \
     AZ_TRACE_METHOD(); \
     AZ_ATOM_PROFILE_TIME_GROUP_REGION(groupName, regionName) \
+
+//! Macro that allows for region names to be submitted at runtime. Use sparingly - this acquires a lock and allocates new objects within a map.
+#define AZ_ATOM_PROFILE_DYNAMIC(groupName, regionName) \
+    static_assert(AZStd::is_convertible_v<decltype(groupName), const char*>, "Runtime group names are not allowed, use a static string literal instead."); \
+    const AZ::RHI::CachedTimeRegion::GroupRegionName& AZ_JOIN(groupRegionName, __LINE__) =                                                                 \
+        AZ::RHI::CpuProfiler::Get()->InsertDynamicName(groupName, regionName);                                                                             \
+    AZ::RHI::TimeRegion AZ_JOIN(timeRegion, __LINE__)(&AZ_JOIN(groupRegionName, __LINE__));
diff --git a/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfilerImpl.h b/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfilerImpl.h
index 7d3b0c5b81..2e4ca67db8 100644
--- a/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfilerImpl.h
+++ b/Gems/Atom/RHI/Code/Include/Atom/RHI/CpuProfilerImpl.h
@@ -13,6 +13,7 @@
 #include <AzCore/Component/TickBus.h>
 #include <AzCore/Memory/OSAllocator.h>
 #include <AzCore/std/containers/map.h>
+#include <AzCore/std/containers/unordered_set.h>
 #include <AzCore/std/parallel/mutex.h>
 #include <AzCore/std/parallel/shared_mutex.h>
 #include <AzCore/std/smart_ptr/intrusive_refcount.h>
@@ -114,9 +115,11 @@ namespace AZ
             bool IsContinuousCaptureInProgress() const final override;
             void SetProfilerEnabled(bool enabled) final override;
             bool IsProfilerEnabled() const final override;
+            const CachedTimeRegion::GroupRegionName& InsertDynamicName(const char* groupName, const AZStd::string& regionName) final override;
 
         private:
             static constexpr AZStd::size_t MaxFramesToSave = 2 * 60 * 120; // 2 minutes of 120fps
+            static constexpr AZStd::size_t MaxRegionStringPoolSize = 16384; // Max amount of unique strings to save in the pool before throwing warnings.
 
             // Lazily create and register the local thread data
             void RegisterThreadStorage();
@@ -129,6 +132,15 @@ namespace AZ
             AZStd::vector<RHI::Ptr<CpuTimingLocalStorage>, AZ::OSStdAllocator> m_registeredThreads;
             AZStd::mutex m_threadRegisterMutex;
 
+            // Pool for GroupRegionNames that are generated at runtime through AZ_ATOM_PROFILE_DYNAMIC. Each unique
+            // combination of group name and region name submitted will be stored in this pool to emulate static lifetime.
+            AZStd::unordered_set<CachedTimeRegion::GroupRegionName, CachedTimeRegion::GroupRegionName::Hash> m_dynamicGroupRegionNamePool;
+
+            // String pool for storing region names submitted at runtime. Each call to AZ_ATOM_PROFILE_DYNAMIC will either construct
+            // a string in this pool or use an already-existing entry.
+            AZStd::unordered_set<AZStd::string> m_regionNameStringPool;
+            AZStd::mutex m_dynamicNameMutex;
+
             // Thread local storage, gets lazily allocated when a thread is created
             static thread_local CpuTimingLocalStorage* ms_threadLocalStorage;
 
diff --git a/Gems/Atom/RHI/Code/Source/RHI/CpuProfilerImpl.cpp b/Gems/Atom/RHI/Code/Source/RHI/CpuProfilerImpl.cpp
index cdfd4ac469..d41b5d656e 100644
--- a/Gems/Atom/RHI/Code/Source/RHI/CpuProfilerImpl.cpp
+++ b/Gems/Atom/RHI/Code/Source/RHI/CpuProfilerImpl.cpp
@@ -74,6 +74,20 @@ namespace AZ
         {
         }
 
+        AZStd::size_t CachedTimeRegion::GroupRegionName::Hash::operator()(const CachedTimeRegion::GroupRegionName& name) const
+        {
+            AZStd::size_t seed = 0;
+            AZStd::hash_combine(seed, name.m_groupName);
+            AZStd::hash_combine(seed, name.m_regionName);
+            return seed;
+        }
+
+        bool CachedTimeRegion::GroupRegionName::operator==(const GroupRegionName& other) const
+        {
+            return (m_groupName == other.m_groupName) && (m_regionName == other.m_regionName);
+        }
+
+
         // --- CpuProfilerImpl ---
 
         void CpuProfilerImpl::Init()
@@ -218,6 +232,19 @@ namespace AZ
             return m_enabled;
         }
 
+        const CachedTimeRegion::GroupRegionName& CpuProfilerImpl::InsertDynamicName(const char* groupName, const AZStd::string& regionName)
+        {
+            AZStd::scoped_lock lock(m_dynamicNameMutex);
+            AZ_Warning("CpuProfiler", m_regionNameStringPool.size() < MaxRegionStringPoolSize,
+                "Stored dynamic region names are accumulating. Consider removing a AZ_ATOM_PROFILE_DYNAMIC invocation.");
+            auto [regionNameItr, wasRegionInserted] =  m_regionNameStringPool.insert(regionName);
+
+            CachedTimeRegion::GroupRegionName newGroupRegionName(groupName, regionNameItr->c_str());
+            auto [groupRegionNameItr, wasGroupRegionInserted] = m_dynamicGroupRegionNamePool.insert(newGroupRegionName);
+
+            return *groupRegionNameItr;
+        }
+
         void CpuProfilerImpl::OnSystemTick()
         {
             if (!m_enabled)