diff --git a/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_DynamicSliceInstanceSpawner.py b/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_DynamicSliceInstanceSpawner.py
index ead1e8779c..9235b302b8 100755
--- a/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_DynamicSliceInstanceSpawner.py
+++ b/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_DynamicSliceInstanceSpawner.py
@@ -16,6 +16,7 @@ import logging
 # Bail on the test if ly_test_tools doesn't exist.
 pytest.importorskip('ly_test_tools')
 import ly_test_tools.environment.file_system as file_system
+import ly_test_tools._internal.pytest_plugin as internal_plugin
 import editor_python_test_tools.hydra_test_utils as hydra
 from ly_remote_console.remote_console_commands import RemoteConsole as RemoteConsole
 
@@ -46,6 +47,11 @@ class TestDynamicSliceInstanceSpawner(object):
     @pytest.mark.parametrize("launcher_platform", ['windows_editor'])
     def test_DynamicSliceInstanceSpawner_DynamicSliceSpawnerWorks(self, request, editor, level, workspace, project,
                                                                   launcher_platform):
+
+        # Skip test if running against Debug build
+        if "debug" in internal_plugin.build_directory:
+            pytest.skip("Does not execute against debug builds.")
+
         # Ensure temp level does not already exist
         file_system.delete([os.path.join(workspace.paths.engine_root(), project, "Levels", level)], True, True)
 
diff --git a/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_EmptyInstanceSpawner.py b/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_EmptyInstanceSpawner.py
index ca71cd2137..83263c614a 100755
--- a/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_EmptyInstanceSpawner.py
+++ b/AutomatedTesting/Gem/PythonTests/largeworlds/dyn_veg/test_EmptyInstanceSpawner.py
@@ -16,6 +16,7 @@ import logging
 # Bail on the test if ly_test_tools doesn't exist.
 pytest.importorskip('ly_test_tools')
 import ly_test_tools.environment.file_system as file_system
+import ly_test_tools._internal.pytest_plugin as internal_plugin
 import editor_python_test_tools.hydra_test_utils as hydra
 
 logger = logging.getLogger(__name__)
@@ -40,6 +41,11 @@ class TestEmptyInstanceSpawner(object):
     @pytest.mark.SUITE_main
     @pytest.mark.dynveg_area
     def test_EmptyInstanceSpawner_EmptySpawnerWorks(self, request, editor, level, launcher_platform):
+
+        # Skip test if running against Debug build
+        if "debug" in internal_plugin.build_directory:
+            pytest.skip("Does not execute against debug builds.")
+
         cfg_args = [level]
 
         expected_lines = [
diff --git a/AutomatedTesting/Gem/PythonTests/largeworlds/landscape_canvas/test_GraphComponentSync.py b/AutomatedTesting/Gem/PythonTests/largeworlds/landscape_canvas/test_GraphComponentSync.py
index 855764fa6f..943d0cb985 100755
--- a/AutomatedTesting/Gem/PythonTests/largeworlds/landscape_canvas/test_GraphComponentSync.py
+++ b/AutomatedTesting/Gem/PythonTests/largeworlds/landscape_canvas/test_GraphComponentSync.py
@@ -23,6 +23,7 @@ import pytest
 # Bail on the test if ly_test_tools doesn't exist.
 pytest.importorskip('ly_test_tools')
 import ly_test_tools.environment.file_system as file_system
+import ly_test_tools._internal.pytest_plugin as internal_plugin
 import editor_python_test_tools.hydra_test_utils as hydra
 
 test_directory = os.path.join(os.path.dirname(__file__), 'EditorScripts')
@@ -46,6 +47,11 @@ class TestGraphComponentSync(object):
     @pytest.mark.BAT
     @pytest.mark.SUITE_main
     def test_LandscapeCanvas_SlotConnections_UpdateComponentReferences(self, request, editor, level, launcher_platform):
+
+        # Skip test if running against Debug build
+        if "debug" in internal_plugin.build_directory:
+            pytest.skip("Does not execute against debug builds.")
+
         cfg_args = [level]
 
         expected_lines = [
@@ -122,6 +128,11 @@ class TestGraphComponentSync(object):
         """
         Verifies a Gradient Mixer can be setup in Landscape Canvas and all references are property set.
         """
+
+        # Skip test if running against Debug build
+        if "debug" in internal_plugin.build_directory:
+            pytest.skip("Does not execute against debug builds.")
+            
         cfg_args = [level]
 
         expected_lines = [