diff --git a/.gitignore b/.gitignore
index e41b92498f..b73c89b1d9 100644
--- a/.gitignore
+++ b/.gitignore
@@ -3,7 +3,6 @@
 .vscode/
 __pycache__
 AssetProcessorTemp/**
-CMakeUserPresets.json
 [Bb]uild/**
 [Oo]ut/**
 [Cc]ache/
diff --git a/Code/Framework/AzCore/AzCore/Debug/Profiler.h b/Code/Framework/AzCore/AzCore/Debug/Profiler.h
index 1d932031ef..f173bb8e17 100644
--- a/Code/Framework/AzCore/AzCore/Debug/Profiler.h
+++ b/Code/Framework/AzCore/AzCore/Debug/Profiler.h
@@ -58,13 +58,15 @@ namespace AZ
         static uint32_t GetSystemID(const char* system);
 
         template<typename... T>
-        static void BeginRegion([[maybe_unused]] const char* system, [[maybe_unused]] char const* eventName, [[maybe_unused]] T const&... args)
+        static void BeginRegion([[maybe_unused]] const char* system, [[maybe_unused]] const char* eventName, [[maybe_unused]] T const&... args)
         {
             // TODO: Verification that the supplied system name corresponds to a known budget
 #if defined(USE_PIX)
             PIXBeginEvent(PIX_COLOR_INDEX(GetSystemID(system) & 0xff), eventName, args...);
 #endif
             // TODO: injecting instrumentation for other profilers
+            // NOTE: external profiler registration won't occur inline in a header necessarily in this manner, but the exact mechanism
+            //       will be introduced in a future PR
         }
 
         static void EndRegion()
diff --git a/Code/Legacy/CryCommon/ProjectDefines.h b/Code/Legacy/CryCommon/ProjectDefines.h
index c7740db95c..f7f73f111b 100644
--- a/Code/Legacy/CryCommon/ProjectDefines.h
+++ b/Code/Legacy/CryCommon/ProjectDefines.h
@@ -173,7 +173,6 @@
 
 #if defined(ENABLE_PROFILING_CODE)
     #define USE_DISK_PROFILER
-    #define ENABLE_LOADING_PROFILER
 #endif
 
 // The maximum number of joints in an animation
diff --git a/Gems/ExpressionEvaluation/Code/Source/ExpressionEvaluationSystemComponent.cpp b/Gems/ExpressionEvaluation/Code/Source/ExpressionEvaluationSystemComponent.cpp
index 09b7bf878b..295d42228d 100644
--- a/Gems/ExpressionEvaluation/Code/Source/ExpressionEvaluationSystemComponent.cpp
+++ b/Gems/ExpressionEvaluation/Code/Source/ExpressionEvaluationSystemComponent.cpp
@@ -514,7 +514,7 @@ namespace ExpressionEvaluation
 
     ExpressionResult ExpressionEvaluationSystemComponent::Evaluate(const ExpressionTree& expressionTree) const
     {
-        AZ_PROFILE_SCOPE("ExpressionEvaluation", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ExpressionEvaluation);
 
         ExpressionResultStack resultStack;
 
diff --git a/Gems/ScriptCanvas/Code/Editor/Nodes/NodeCreateUtils.cpp b/Gems/ScriptCanvas/Code/Editor/Nodes/NodeCreateUtils.cpp
index bb3a28099e..3bcd940a01 100644
--- a/Gems/ScriptCanvas/Code/Editor/Nodes/NodeCreateUtils.cpp
+++ b/Gems/ScriptCanvas/Code/Editor/Nodes/NodeCreateUtils.cpp
@@ -99,7 +99,7 @@ namespace ScriptCanvasEditor::Nodes
 
     AZStd::pair<ScriptCanvas::Node*, NodeIdPair> CreateAndGetNode(const AZ::Uuid& classId, const ScriptCanvas::ScriptCanvasId& scriptCanvasId, const StyleConfiguration& styleConfiguration, AZStd::function<void(ScriptCanvas::Node*)> onCreateCallback)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIdPair;
 
         ScriptCanvas::Node* node{};
@@ -134,7 +134,7 @@ namespace ScriptCanvasEditor::Nodes
 
     NodeIdPair CreateObjectMethodNode(AZStd::string_view className, AZStd::string_view methodName, const ScriptCanvas::ScriptCanvasId& scriptCanvasId, ScriptCanvas::PropertyStatus propertyStatus)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIds;
 
         ScriptCanvas::Node* node = nullptr;
@@ -161,7 +161,7 @@ namespace ScriptCanvasEditor::Nodes
 
     NodeIdPair CreateObjectMethodOverloadNode(AZStd::string_view className, AZStd::string_view methodName, const ScriptCanvas::ScriptCanvasId& scriptCanvasGraphId)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIds;
 
         ScriptCanvas::Node* node = nullptr;
@@ -188,7 +188,7 @@ namespace ScriptCanvasEditor::Nodes
 
     NodeIdPair CreateGlobalMethodNode(AZStd::string_view methodName, const ScriptCanvas::ScriptCanvasId& scriptCanvasId)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIds;
 
         ScriptCanvas::Node* node = nullptr;
@@ -215,7 +215,7 @@ namespace ScriptCanvasEditor::Nodes
 
     NodeIdPair CreateEbusWrapperNode(AZStd::string_view busName, const ScriptCanvas::ScriptCanvasId& scriptCanvasId)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIdPair;
 
         ScriptCanvas::Node* node = nullptr;
@@ -241,7 +241,7 @@ namespace ScriptCanvasEditor::Nodes
     {
         AZ_Assert(assetId.IsValid(), "CreateScriptEventReceiverNode asset Id must be valid");
 
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIdPair;
 
         AZ::Data::Asset<ScriptEvents::ScriptEventsAsset> asset = AZ::Data::AssetManager::Instance().GetAsset<ScriptEvents::ScriptEventsAsset>(assetId, AZ::Data::AssetLoadBehavior::Default);
@@ -276,7 +276,7 @@ namespace ScriptCanvasEditor::Nodes
     {
         AZ_Assert(assetId.IsValid(), "CreateScriptEventSenderNode asset Id must be valid");
 
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIdPair;
 
         AZ::Data::Asset<ScriptEvents::ScriptEventsAsset> asset = AZ::Data::AssetManager::Instance().GetAsset<ScriptEvents::ScriptEventsAsset>(assetId, AZ::Data::AssetLoadBehavior::Default);
@@ -302,7 +302,7 @@ namespace ScriptCanvasEditor::Nodes
 
     NodeIdPair CreateGetVariableNode(const ScriptCanvas::VariableId& variableId, ScriptCanvas::ScriptCanvasId scriptCanvasId)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         const AZ::Uuid k_VariableNodeTypeId = azrtti_typeid<ScriptCanvas::Nodes::Core::GetVariableNode>();
 
         NodeIdPair nodeIds;
@@ -333,7 +333,7 @@ namespace ScriptCanvasEditor::Nodes
 
     NodeIdPair CreateSetVariableNode(const ScriptCanvas::VariableId& variableId, ScriptCanvas::ScriptCanvasId scriptCanvasId)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         const AZ::Uuid k_VariableNodeTypeId = azrtti_typeid<ScriptCanvas::Nodes::Core::SetVariableNode>();
 
         NodeIdPair nodeIds;
@@ -366,7 +366,7 @@ namespace ScriptCanvasEditor::Nodes
     {
         AZ_Assert(assetId.IsValid(), "CreateFunctionNode source asset Id must be valid");
 
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIdPair;
 
         AZ::Data::Asset<ScriptCanvas::SubgraphInterfaceAsset> asset = AZ::Data::AssetManager::Instance().GetAsset<ScriptCanvas::SubgraphInterfaceAsset>(assetId, AZ::Data::AssetLoadBehavior::PreLoad);
@@ -394,7 +394,7 @@ namespace ScriptCanvasEditor::Nodes
     NodeIdPair CreateAzEventHandlerNode(const AZ::BehaviorMethod& methodWithAzEventReturn, ScriptCanvas::ScriptCanvasId scriptCanvasId,
         AZ::EntityId connectingMethodNodeId)
     {
-        AZ_PROFILE_SCOPE("ScriptCanvas", __FUNCTION__);
+        AZ_PROFILE_FUNCTION(ScriptCanvas);
         NodeIdPair nodeIdPair;
 
         // Make sure the method returns an AZ::Event by reference or pointer