diff --git a/Code/Editor/MainWindow.cpp b/Code/Editor/MainWindow.cpp
index 14ba902b15..d693812e3d 100644
--- a/Code/Editor/MainWindow.cpp
+++ b/Code/Editor/MainWindow.cpp
@@ -519,7 +519,7 @@ MainWindow* MainWindow::instance()
 
 void MainWindow::closeEvent(QCloseEvent* event)
 {
-    gSettings.Save();
+    gSettings.Save(true);
 
     AzFramework::SystemCursorState currentCursorState;
     bool isInGameMode = false;
diff --git a/Code/Editor/Settings.cpp b/Code/Editor/Settings.cpp
index 147ed0c0b8..acb48c3545 100644
--- a/Code/Editor/Settings.cpp
+++ b/Code/Editor/Settings.cpp
@@ -471,7 +471,7 @@ void SEditorSettings::LoadValue(const char* sSection, const char* sKey, ESystemC
 }
 
 //////////////////////////////////////////////////////////////////////////
-void SEditorSettings::Save()
+void SEditorSettings::Save(bool isEditorClosing)
 {
     QString strStringPlaceholder;
 
@@ -638,14 +638,16 @@ void SEditorSettings::Save()
     // --- Settings Registry values
 
     // Prefab System UI
-    AzFramework::ApplicationRequests::Bus::Broadcast(
-        &AzFramework::ApplicationRequests::SetPrefabSystemEnabled, prefabSystem);
+    AzFramework::ApplicationRequests::Bus::Broadcast(&AzFramework::ApplicationRequests::SetPrefabSystemEnabled, prefabSystem);
 
     AzToolsFramework::Prefab::PrefabLoaderInterface* prefabLoaderInterface =
         AZ::Interface<AzToolsFramework::Prefab::PrefabLoaderInterface>::Get();
     prefabLoaderInterface->SetSaveAllPrefabsPreference(levelSaveSettings.saveAllPrefabsPreference);
 
-    SaveSettingsRegistryFile();
+    if (!isEditorClosing)
+    {
+        SaveSettingsRegistryFile();
+    }
 }
 
 //////////////////////////////////////////////////////////////////////////
diff --git a/Code/Editor/Settings.h b/Code/Editor/Settings.h
index f4a6dabde8..9276d9b715 100644
--- a/Code/Editor/Settings.h
+++ b/Code/Editor/Settings.h
@@ -267,7 +267,7 @@ struct SANDBOX_API SEditorSettings
 AZ_POP_DISABLE_DLL_EXPORT_BASECLASS_WARNING
     SEditorSettings();
     ~SEditorSettings() = default;
-    void    Save();
+    void    Save(bool isEditorClosing = false);
     void    Load();
     void    LoadCloudSettings();