diff --git a/Gems/ScriptCanvas/Code/Include/ScriptCanvas/Execution/Interpreted/ExecutionInterpretedAPI.cpp b/Gems/ScriptCanvas/Code/Include/ScriptCanvas/Execution/Interpreted/ExecutionInterpretedAPI.cpp
index 8d324e95c0..4d7c8a2cda 100644
--- a/Gems/ScriptCanvas/Code/Include/ScriptCanvas/Execution/Interpreted/ExecutionInterpretedAPI.cpp
+++ b/Gems/ScriptCanvas/Code/Include/ScriptCanvas/Execution/Interpreted/ExecutionInterpretedAPI.cpp
@@ -503,7 +503,7 @@ namespace ScriptCanvas
 
         void InitializeInterpretedStatics(const RuntimeData& runtimeData)
         {
-#if defined(PROFILE) || defined(AZ_DEBUG_BUILD)
+#if defined(AZ_PROFILE_BUILD) || defined(AZ_DEBUG_BUILD)
             Execution::InitializeFromLuaStackFunctions(const_cast<Grammar::DebugSymbolMap&>(runtimeData.m_debugMap));
 #endif
             if (runtimeData.RequiresStaticInitialization())
diff --git a/cmake/Platform/Common/Configurations_common.cmake b/cmake/Platform/Common/Configurations_common.cmake
index 15f7344958..d16dfa3eea 100644
--- a/cmake/Platform/Common/Configurations_common.cmake
+++ b/cmake/Platform/Common/Configurations_common.cmake
@@ -36,7 +36,7 @@ ly_append_configurations_options(
         AZ_BUILD_CONFIGURATION_TYPE="${LY_BUILD_CONFIGURATION_TYPE_DEBUG}"
     DEFINES_PROFILE
         _PROFILE
-        PROFILE
+        AZ_PROFILE_BUILD=1
         NDEBUG
         AZ_ENABLE_TRACING
         AZ_ENABLE_DEBUG_TOOLS