diff --git a/Gems/Atom/Asset/Shader/Code/Source/Editor/AzslShaderBuilderSystemComponent.cpp b/Gems/Atom/Asset/Shader/Code/Source/Editor/AzslShaderBuilderSystemComponent.cpp
index eae4e804e0..7e510e2e3a 100644
--- a/Gems/Atom/Asset/Shader/Code/Source/Editor/AzslShaderBuilderSystemComponent.cpp
+++ b/Gems/Atom/Asset/Shader/Code/Source/Editor/AzslShaderBuilderSystemComponent.cpp
@@ -82,7 +82,7 @@ namespace AZ
             // Register Shader Asset Builder
             AssetBuilderSDK::AssetBuilderDesc shaderAssetBuilderDescriptor;
             shaderAssetBuilderDescriptor.m_name = "Shader Asset Builder";
-            shaderAssetBuilderDescriptor.m_version = 109; // Modify Metal shader platform to permit the precise keyword to fix depth bitwise mismatch between passes
+            shaderAssetBuilderDescriptor.m_version = 110; // Add "Definitions" field to shader asset to support convenient addition of preprocessor definitions
             shaderAssetBuilderDescriptor.m_patterns.push_back(AssetBuilderSDK::AssetBuilderPattern( AZStd::string::format("*.%s", RPI::ShaderSourceData::Extension), AssetBuilderSDK::AssetBuilderPattern::PatternType::Wildcard));
             shaderAssetBuilderDescriptor.m_busId = azrtti_typeid<ShaderAssetBuilder>();
             shaderAssetBuilderDescriptor.m_createJobFunction = AZStd::bind(&ShaderAssetBuilder::CreateJobs, &m_shaderAssetBuilder, AZStd::placeholders::_1, AZStd::placeholders::_2);
diff --git a/Gems/Atom/Asset/Shader/Code/Source/Editor/ShaderAssetBuilder.cpp b/Gems/Atom/Asset/Shader/Code/Source/Editor/ShaderAssetBuilder.cpp
index e431b74282..341f737bd6 100644
--- a/Gems/Atom/Asset/Shader/Code/Source/Editor/ShaderAssetBuilder.cpp
+++ b/Gems/Atom/Asset/Shader/Code/Source/Editor/ShaderAssetBuilder.cpp
@@ -413,6 +413,9 @@ namespace AZ
             // At this moment We have global build options that should be merged with the build options that are common
             // to all the supervariants of this shader.
             buildOptions.m_compilerArguments.Merge(shaderSourceData.m_compiler);
+            buildOptions.m_preprocessorSettings.m_predefinedMacros.insert(
+                buildOptions.m_preprocessorSettings.m_predefinedMacros.end(),
+                shaderSourceData.m_definitions.begin(), shaderSourceData.m_definitions.end());
 
             for (RHI::ShaderPlatformInterface* shaderPlatformInterface : platformInterfaces)
             {
diff --git a/Gems/Atom/RPI/Code/Include/Atom/RPI.Edit/Shader/ShaderSourceData.h b/Gems/Atom/RPI/Code/Include/Atom/RPI.Edit/Shader/ShaderSourceData.h
index 7742450bd6..a7d28eab14 100644
--- a/Gems/Atom/RPI/Code/Include/Atom/RPI.Edit/Shader/ShaderSourceData.h
+++ b/Gems/Atom/RPI/Code/Include/Atom/RPI.Edit/Shader/ShaderSourceData.h
@@ -57,6 +57,7 @@ namespace AZ
             };
 
             AZStd::string m_source;
+            AZStd::vector<AZStd::string> m_definitions;
             RHI::ShaderCompilerArguments m_compiler;
 
             AZStd::string m_drawListName;
diff --git a/Gems/Atom/RPI/Code/Source/RPI.Edit/Shader/ShaderSourceData.cpp b/Gems/Atom/RPI/Code/Source/RPI.Edit/Shader/ShaderSourceData.cpp
index 20bd36784f..d0abd89af0 100644
--- a/Gems/Atom/RPI/Code/Source/RPI.Edit/Shader/ShaderSourceData.cpp
+++ b/Gems/Atom/RPI/Code/Source/RPI.Edit/Shader/ShaderSourceData.cpp
@@ -21,13 +21,14 @@ namespace AZ
             if (auto* serializeContext = azrtti_cast<SerializeContext*>(context))
             {
                 serializeContext->Class<ShaderSourceData>()
-                    ->Version(4)
+                    ->Version(5)
                     ->Field("Source", &ShaderSourceData::m_source)
                     ->Field("DrawList", &ShaderSourceData::m_drawListName)
                     ->Field("DepthStencilState", &ShaderSourceData::m_depthStencilState)
                     ->Field("RasterState", &ShaderSourceData::m_rasterState)
                     ->Field("BlendState", &ShaderSourceData::m_blendState)
                     ->Field("ProgramSettings", &ShaderSourceData::m_programSettings)
+                    ->Field("Definitions", &ShaderSourceData::m_definitions)
                     ->Field("CompilerHints", &ShaderSourceData::m_compiler)
                     ->Field("DisabledRHIBackends", &ShaderSourceData::m_disabledRhiBackends)
                     ->Field("Supervariants", &ShaderSourceData::m_supervariants)