diff --git a/Code/CryEngine/CryCommon/AppleSpecific.h b/Code/CryEngine/CryCommon/AppleSpecific.h
index 523332e9d3..830825f6cd 100644
--- a/Code/CryEngine/CryCommon/AppleSpecific.h
+++ b/Code/CryEngine/CryCommon/AppleSpecific.h
@@ -140,7 +140,10 @@ typedef uint8                               byte;
 #define STDMETHODCALLTYPE
 #endif
 
-#define _ALIGN(num) __attribute__ ((aligned(num)))
+#define _ALIGN(num) \
+    __attribute__ ((aligned(num))) \
+    AZ_POP_DISABLE_WARNING
+
 #define _PACK __attribute__ ((packed))
 
 // Safe memory freeing
diff --git a/Code/CryEngine/CryCommon/LinuxSpecific.h b/Code/CryEngine/CryCommon/LinuxSpecific.h
index 85abf0ff53..361e31c791 100644
--- a/Code/CryEngine/CryCommon/LinuxSpecific.h
+++ b/Code/CryEngine/CryCommon/LinuxSpecific.h
@@ -104,7 +104,10 @@ typedef float FLOAT;
 #define STDMETHODCALLTYPE
 #endif
 
-#define _ALIGN(num) __attribute__ ((aligned(num)))
+#define _ALIGN(num) \
+    __attribute__ ((aligned(num))) \
+    AZ_POP_DISABLE_WARNING
+
 #define _PACK __attribute__ ((packed))
 
 // Safe memory freeing
diff --git a/Code/CryEngine/CryCommon/Win32specific.h b/Code/CryEngine/CryCommon/Win32specific.h
index 189bd8770b..9b8a8f75f4 100644
--- a/Code/CryEngine/CryCommon/Win32specific.h
+++ b/Code/CryEngine/CryCommon/Win32specific.h
@@ -111,7 +111,9 @@ int64 CryGetTicksPerSec();
 }
 #endif
 
-#define _MS_ALIGN(num) __declspec(align(num))
+#define _MS_ALIGN(num) \
+    AZ_PUSH_DISABLE_WARNING(4324, "-Wunknown-warning-option") \
+    __declspec(align(num))
 
 #define DEFINE_ALIGNED_DATA(type, name, alignment) _declspec(align(alignment)) type name;
 #define DEFINE_ALIGNED_DATA_STATIC(type, name, alignment) static _declspec(align(alignment)) type name;
diff --git a/Code/CryEngine/CryCommon/Win64specific.h b/Code/CryEngine/CryCommon/Win64specific.h
index 00af315376..aac2b40621 100644
--- a/Code/CryEngine/CryCommon/Win64specific.h
+++ b/Code/CryEngine/CryCommon/Win64specific.h
@@ -93,7 +93,9 @@ int64 CryGetTicksPerSec();
 }
 #endif
 
-#define _MS_ALIGN(num) __declspec(align(num))
+#define _MS_ALIGN(num) \
+    AZ_PUSH_DISABLE_WARNING(4324, "-Wunknown-warning-option") \
+    __declspec(align(num))
 
 #define DEFINE_ALIGNED_DATA(type, name, alignment) _declspec(align(alignment)) type name;
 #define DEFINE_ALIGNED_DATA_STATIC(type, name, alignment) static _declspec(align(alignment)) type name;
diff --git a/Code/CryEngine/CryCommon/platform.h b/Code/CryEngine/CryCommon/platform.h
index df8fb125b2..0e026d7113 100644
--- a/Code/CryEngine/CryCommon/platform.h
+++ b/Code/CryEngine/CryCommon/platform.h
@@ -733,12 +733,12 @@ enum ETriState
 
 // Fallback for Alignment macro of GCC/CLANG (must be after the class definition)
 #if !defined(_ALIGN)
-        #define _ALIGN(num)
+        #define _ALIGN(num) AZ_POP_DISABLE_WARNING
 #endif
 
 // Fallback for Alignment macro of MSVC (must be before the class definition)
 #if !defined(_MS_ALIGN)
-        #define _MS_ALIGN(num)
+        #define _MS_ALIGN(num) AZ_PUSH_DISABLE_WARNING(4324, "-Wunknown-warning-option")
 #endif
 
 #if defined(WIN32) || defined(WIN64)
diff --git a/Code/Framework/AzCore/AzCore/PlatformDef.h b/Code/Framework/AzCore/AzCore/PlatformDef.h
index d2a254356a..03c97cf965 100644
--- a/Code/Framework/AzCore/AzCore/PlatformDef.h
+++ b/Code/Framework/AzCore/AzCore/PlatformDef.h
@@ -96,7 +96,12 @@
 #endif
 
 /// Aligns a declaration.
-#   define AZ_ALIGN(_decl, _alignment) __declspec(align(_alignment)) _decl
+#   define AZ_ALIGN(_decl, _alignment) \
+    AZ_PUSH_DISABLE_WARNING(4324, "-Wunknown-warning-option") \
+    __declspec(align(_alignment)) \
+    _decl \
+    AZ_POP_DISABLE_WARNING
+
 /// Return the alignment of a type. This if for internal use only (use AZStd::alignment_of<>())
 #   define AZ_INTERNAL_ALIGNMENT_OF(_type) __alignof(_type)
 /// Pointer will be aliased.
@@ -123,7 +128,12 @@
 
 #   define AZ_FORCE_INLINE  inline
 /// Aligns a declaration.
-#   define AZ_ALIGN(_decl, _alignment) _decl __attribute__((aligned(_alignment)))
+#   define AZ_ALIGN(_decl, _alignment) \
+    AZ_PUSH_DISABLE_WARNING(4324, "-Wunknown-warning-option") \
+    _decl \
+    __attribute__((aligned(_alignment)))
+    AZ_POP_DISABLE_WARNING
+
 /// Return the alignment of a type. This if for internal use only (use AZStd::alignment_of<>())
 #   define AZ_INTERNAL_ALIGNMENT_OF(_type) __alignof__(_type)
 /// Pointer will be aliased.
diff --git a/Code/Framework/AzNetworking/AzNetworking/Utilities/QuantizedValues.h b/Code/Framework/AzNetworking/AzNetworking/Utilities/QuantizedValues.h
index ccdedb85c5..aa11d4fc7f 100644
--- a/Code/Framework/AzNetworking/AzNetworking/Utilities/QuantizedValues.h
+++ b/Code/Framework/AzNetworking/AzNetworking/Utilities/QuantizedValues.h
@@ -180,10 +180,7 @@ namespace AzNetworking
         //! Takes a quantized integral value and stores the floating point representation.
         void DecodeQuantizedValues();
 
-#   if defined AZ_COMPILER_MSVC
-#       pragma warning(push)
-#       pragma warning(disable:4201) // anonymous union
-#   endif
+        AZ_PUSH_DISABLE_WARNING(4201 4324, "-Wunknown-warning-option") // anonymous union, structure was padded due to alignment
         union
         {
             float m_quantizedValues[NUM_ELEMENTS];
@@ -195,9 +192,7 @@ namespace AzNetworking
             uint32_t m_serializeValues[NUM_ELEMENTS];
             SimdTypei m_serializeVector;
         };
-#   if defined AZ_COMPILER_MSVC
-#       pragma warning(pop)
-#   endif
+        AZ_POP_DISABLE_WARNING
 
         template <AZStd::size_t NUM_ELEMENTS2, AZStd::size_t NUM_BYTES2, int32_t MIN_VALUE2, int32_t MAX_VALUE2>
         friend struct QuantizedValuesConversionHelper;
diff --git a/Gems/EMotionFX/Code/Tests/Matchers.h b/Gems/EMotionFX/Code/Tests/Matchers.h
index b14d6a6a78..a94d02f51b 100644
--- a/Gems/EMotionFX/Code/Tests/Matchers.h
+++ b/Gems/EMotionFX/Code/Tests/Matchers.h
@@ -29,7 +29,7 @@ StrEq(const AZStd::string& str)
       str, true, true));
 }
 
-AZ_PUSH_DISABLE_WARNING(4100, "-Wmissing-declarations") // 'result_listener': unreferenced formal parameter
+AZ_PUSH_DISABLE_WARNING(4100 4324, "-Wmissing-declarations") // 'result_listener': unreferenced formal parameter, structure was padded due to alignment specifier
 MATCHER(StrEq, "")
 {
     const auto& lhs = testing::get<0>(arg);
diff --git a/cmake/Platform/Common/MSVC/Configurations_msvc.cmake b/cmake/Platform/Common/MSVC/Configurations_msvc.cmake
index bcff2adeb7..b07a87a35a 100644
--- a/cmake/Platform/Common/MSVC/Configurations_msvc.cmake
+++ b/cmake/Platform/Common/MSVC/Configurations_msvc.cmake
@@ -63,12 +63,10 @@ ly_append_configurations_options(
 
         # Disabling these warnings while they get fixed
         /wd4018 # signed/unsigned mismatch
-        /wd4121 # alignment of a member was sensitive to packing
         /wd4244 # conversion, possible loss of data
         /wd4245 # conversion, signed/unsigned mismatch
         /wd4267 # conversion, possible loss of data
         /wd4310 # cast truncates constant value
-        /wd4324 # structure was padded due to alignment specifier
         /wd4389 # comparison, signed/unsigned mismatch
 
         # Enabling warnings that are disabled by default from /W4