diff --git a/Code/Editor/CryEditDoc.cpp b/Code/Editor/CryEditDoc.cpp
index 76704a3f07..a61429fc87 100644
--- a/Code/Editor/CryEditDoc.cpp
+++ b/Code/Editor/CryEditDoc.cpp
@@ -132,14 +132,19 @@ CCryEditDoc::CCryEditDoc()
     RegisterConsoleVariables();
 
     MainWindow::instance()->GetActionManager()->RegisterActionHandler(ID_FILE_SAVE_AS, this, &CCryEditDoc::OnFileSaveAs);
-    m_prefabSystemComponentInterface = AZ::Interface<AzToolsFramework::Prefab::PrefabSystemComponentInterface>::Get();
-    AZ_Assert(m_prefabSystemComponentInterface, "PrefabSystemComponentInterface is not found.");
-    m_prefabEditorEntityOwnershipInterface = AZ::Interface<AzToolsFramework::PrefabEditorEntityOwnershipInterface>::Get();
-    AZ_Assert(m_prefabEditorEntityOwnershipInterface, "PrefabEditorEntityOwnershipInterface is not found.");
-    m_prefabLoaderInterface = AZ::Interface<AzToolsFramework::Prefab::PrefabLoaderInterface>::Get();
-    AZ_Assert(m_prefabLoaderInterface, "PrefabLoaderInterface is not found.");
-    m_prefabIntegrationInterface = AZ::Interface<AzToolsFramework::Prefab::PrefabIntegrationInterface>::Get();
-    AZ_Assert(m_prefabIntegrationInterface, "PrefabIntegrationInterface is not found.");
+    bool isPrefabSystemEnabled = false;
+    AzFramework::ApplicationRequests::Bus::BroadcastResult(isPrefabSystemEnabled, &AzFramework::ApplicationRequests::IsPrefabSystemEnabled);
+    if (isPrefabSystemEnabled)
+    {
+        m_prefabSystemComponentInterface = AZ::Interface<AzToolsFramework::Prefab::PrefabSystemComponentInterface>::Get();
+        AZ_Assert(m_prefabSystemComponentInterface, "PrefabSystemComponentInterface is not found.");
+        m_prefabEditorEntityOwnershipInterface = AZ::Interface<AzToolsFramework::PrefabEditorEntityOwnershipInterface>::Get();
+        AZ_Assert(m_prefabEditorEntityOwnershipInterface, "PrefabEditorEntityOwnershipInterface is not found.");
+        m_prefabLoaderInterface = AZ::Interface<AzToolsFramework::Prefab::PrefabLoaderInterface>::Get();
+        AZ_Assert(m_prefabLoaderInterface, "PrefabLoaderInterface is not found.");
+        m_prefabIntegrationInterface = AZ::Interface<AzToolsFramework::Prefab::PrefabIntegrationInterface>::Get();
+        AZ_Assert(m_prefabIntegrationInterface, "PrefabIntegrationInterface is not found.");
+    }
 }
 
 CCryEditDoc::~CCryEditDoc()