diff --git a/Gems/Atom/Asset/Shader/Code/CMakeLists.txt b/Gems/Atom/Asset/Shader/Code/CMakeLists.txt
index efbedb0a38..ed5aa45bbf 100644
--- a/Gems/Atom/Asset/Shader/Code/CMakeLists.txt
+++ b/Gems/Atom/Asset/Shader/Code/CMakeLists.txt
@@ -53,7 +53,6 @@ ly_add_target(
             ${pal_source_dir}
     COMPILE_DEFINITIONS
         PRIVATE
-            NOT_USE_CRY_MEMORY_MANAGER
             _SCL_SECURE_NO_WARNINGS
     BUILD_DEPENDENCIES
         PUBLIC
diff --git a/Gems/ScriptCanvasDeveloper/Code/CMakeLists.txt b/Gems/ScriptCanvasDeveloper/Code/CMakeLists.txt
index dd785306a5..6271531e97 100644
--- a/Gems/ScriptCanvasDeveloper/Code/CMakeLists.txt
+++ b/Gems/ScriptCanvasDeveloper/Code/CMakeLists.txt
@@ -8,7 +8,6 @@
 
 set(SCRIPT_CANVAS_DEV_COMMON_DEFINES
     SCRIPTCANVASDEVELOPER
-    NOT_USE_CRY_MEMORY_MANAGER
     AZCORE_ENABLE_MEMORY_TRACKING
 )