diff --git a/cmake/Platform/Common/Install_common.cmake b/cmake/Platform/Common/Install_common.cmake
index 86f46a6e0b..fdd3256d78 100644
--- a/cmake/Platform/Common/Install_common.cmake
+++ b/cmake/Platform/Common/Install_common.cmake
@@ -23,12 +23,12 @@ ly_set(CMAKE_INSTALL_DEFAULT_COMPONENT_NAME Core)
 
 cmake_path(RELATIVE_PATH CMAKE_RUNTIME_OUTPUT_DIRECTORY BASE_DIRECTORY ${CMAKE_BINARY_DIR} OUTPUT_VARIABLE runtime_output_directory)
 cmake_path(RELATIVE_PATH CMAKE_LIBRARY_OUTPUT_DIRECTORY BASE_DIRECTORY ${CMAKE_BINARY_DIR} OUTPUT_VARIABLE library_output_directory)
-# Anywhere CMAKE_INSTALL_PREFIX is used, it has to be escaped so it is baked into the cmake_install.cmake script instead
-# of baking the path. This is needed so `cmake --install --prefix <someprefix>` works regardless of the CMAKE_INSTALL_PREFIX
-# used to generate the solution.
-# CMAKE_INSTALL_PREFIX is still used when building the INSTALL target
-set(install_output_folder "\${CMAKE_INSTALL_PREFIX}/${runtime_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>")
 
+if(LY_MONOLITHIC_GAME)
+    set(LY_BUILD_PERMUTATION Monolithic)
+else()
+    set(LY_BUILD_PERMUTATION Default)
+endif()
 
 #! ly_setup_target: Setup the data needed to re-create the cmake target commands for a single target
 function(ly_setup_target OUTPUT_CONFIGURED_TARGET ALIAS_TARGET_NAME absolute_target_source_dir)
@@ -91,6 +91,10 @@ function(ly_setup_target OUTPUT_CONFIGURED_TARGET ALIAS_TARGET_NAME absolute_tar
         cmake_path(RELATIVE_PATH target_library_output_directory BASE_DIRECTORY ${CMAKE_LIBRARY_OUTPUT_DIRECTORY} OUTPUT_VARIABLE target_library_output_subdirectory)
     endif()
 
+    cmake_path(APPEND archive_output_directory "${PAL_PLATFORM_NAME}/$<CONFIG>/${LY_BUILD_PERMUTATION}")
+    cmake_path(APPEND library_output_directory "${PAL_PLATFORM_NAME}/$<CONFIG>/${LY_BUILD_PERMUTATION}")
+    cmake_path(APPEND runtime_output_directory "${PAL_PLATFORM_NAME}/$<CONFIG>/${LY_BUILD_PERMUTATION}")
+
     if(COMMAND ly_install_target_override)
         # Mac needs special handling because of a cmake issue
         ly_install_target_override(TARGET ${TARGET_NAME}
@@ -104,18 +108,18 @@ function(ly_setup_target OUTPUT_CONFIGURED_TARGET ALIAS_TARGET_NAME absolute_tar
         install(
             TARGETS ${TARGET_NAME}
             ARCHIVE
-                DESTINATION ${archive_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>
+                DESTINATION ${archive_output_directory}
                 COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
             LIBRARY
-                DESTINATION ${library_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/${target_library_output_subdirectory}
+                DESTINATION ${library_output_directory}/${target_library_output_subdirectory}
                 COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
             RUNTIME
-                DESTINATION ${runtime_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/${target_runtime_output_subdirectory}
+                DESTINATION ${runtime_output_directory}/${target_runtime_output_subdirectory}
                 COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
         )
     endif()
 
-    # CMakeLists.txt file
+    # CMakeLists.txt related files
     string(REGEX MATCH "(.*)::(.*)$" match ${ALIAS_TARGET_NAME})
     if(match)
         set(NAMESPACE_PLACEHOLDER "NAMESPACE ${CMAKE_MATCH_1}")
@@ -140,7 +144,7 @@ function(ly_setup_target OUTPUT_CONFIGURED_TARGET ALIAS_TARGET_NAME absolute_tar
     if(TARGET_TYPE_PLACEHOLDER IN_LIST GEM_LIBRARY_TYPES)
         get_target_property(gem_module ${TARGET_NAME} GEM_MODULE)
         if(gem_module)
-            set(TARGET_TYPE_PLACEHOLDER "GEM_MODULE")
+            string(PREPEND TARGET_TYPE_PLACEHOLDER "GEM_")
         endif()
     endif()
 
@@ -222,32 +226,32 @@ set_target_properties(${RUN_TARGET_NAME} PROPERTIES
 )
     endif()
 
-    # Config file
+    # Config files
     set(target_file_contents "# Generated by O3DE install\n\n")
     if(NOT target_type STREQUAL INTERFACE_LIBRARY)
 
         unset(target_location)
         set(runtime_types EXECUTABLE APPLICATION)
         if(target_type IN_LIST runtime_types)
-            set(target_location "\${LY_ROOT_FOLDER}/${runtime_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/${target_runtime_output_subdirectory}/$<TARGET_FILE_NAME:${TARGET_NAME}>")
+            set(target_location "\${LY_ROOT_FOLDER}/${runtime_output_directory}/${target_runtime_output_subdirectory}/$<TARGET_FILE_NAME:${TARGET_NAME}>")
         elseif(target_type STREQUAL MODULE_LIBRARY)
-            set(target_location "\${LY_ROOT_FOLDER}/${library_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/${target_library_output_subdirectory}/$<TARGET_FILE_NAME:${TARGET_NAME}>")
+            set(target_location "\${LY_ROOT_FOLDER}/${library_output_directory}/${target_library_output_subdirectory}/$<TARGET_FILE_NAME:${TARGET_NAME}>")
         elseif(target_type STREQUAL SHARED_LIBRARY)
             string(APPEND target_file_contents 
 "set_property(TARGET ${NAME_PLACEHOLDER} 
     APPEND_STRING PROPERTY IMPORTED_IMPLIB
-        $<$<CONFIG:$<CONFIG>$<ANGLE-R>:\"\${LY_ROOT_FOLDER}/${archive_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/$<TARGET_LINKER_FILE_NAME:${TARGET_NAME}>\"$<ANGLE-R>
+        $<$<CONFIG:$<CONFIG>$<ANGLE-R>:\"\${LY_ROOT_FOLDER}/${archive_output_directory}/$<TARGET_LINKER_FILE_NAME:${TARGET_NAME}>\"$<ANGLE-R>
 )
 ")
             string(APPEND target_file_contents 
 "set_property(TARGET ${NAME_PLACEHOLDER} 
     PROPERTY IMPORTED_IMPLIB_$<UPPER_CASE:$<CONFIG>> 
-        \"\${LY_ROOT_FOLDER}/${archive_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/$<TARGET_LINKER_FILE_NAME:${TARGET_NAME}>\"
+        \"\${LY_ROOT_FOLDER}/${archive_output_directory}/$<TARGET_LINKER_FILE_NAME:${TARGET_NAME}>\"
 )
 ")
-            set(target_location "\${LY_ROOT_FOLDER}/${library_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/${target_library_output_subdirectory}/$<TARGET_FILE_NAME:${TARGET_NAME}>")
+            set(target_location "\${LY_ROOT_FOLDER}/${library_output_directory}/${target_library_output_subdirectory}/$<TARGET_FILE_NAME:${TARGET_NAME}>")
         else() # STATIC_LIBRARY, OBJECT_LIBRARY, INTERFACE_LIBRARY
-            set(target_location "\${LY_ROOT_FOLDER}/${archive_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/$<TARGET_LINKER_FILE_NAME:${TARGET_NAME}>")
+            set(target_location "\${LY_ROOT_FOLDER}/${archive_output_directory}/$<TARGET_LINKER_FILE_NAME:${TARGET_NAME}>")
         endif()
 
         if(target_location)
@@ -265,9 +269,9 @@ set_property(TARGET ${NAME_PLACEHOLDER}
     endif()
 
     set(target_install_source_dir ${CMAKE_CURRENT_BINARY_DIR}/install/${relative_target_source_dir})
-    file(GENERATE OUTPUT "${target_install_source_dir}/${NAME_PLACEHOLDER}_$<CONFIG>.cmake" CONTENT "${target_file_contents}")
-    install(FILES "${target_install_source_dir}/${NAME_PLACEHOLDER}_$<CONFIG>.cmake"
-        DESTINATION ${relative_target_source_dir}
+    file(GENERATE OUTPUT "${target_install_source_dir}/Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}/${NAME_PLACEHOLDER}_$<CONFIG>.cmake" CONTENT "${target_file_contents}")
+    install(FILES "${target_install_source_dir}/Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}/${NAME_PLACEHOLDER}_$<CONFIG>.cmake"
+        DESTINATION ${relative_target_source_dir}/Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}
         COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
     )
 
@@ -299,16 +303,44 @@ function(ly_setup_subdirectory absolute_target_source_dir)
         string(APPEND all_configured_targets "${configured_target}")
     endforeach()
 
+    # Initialize the target install source directory to path underneath the current binary directory
+    set(target_install_source_dir "${CMAKE_CURRENT_BINARY_DIR}/install/${relative_target_source_dir}")
+
+    ly_file_read(${LY_ROOT_FOLDER}/cmake/install/Copyright.in cmake_copyright_comment)
+
+    # 1. Create the base CMakeLists.txt that will just include a cmake file per platform
+    file(CONFIGURE OUTPUT "${target_install_source_dir}/CMakeLists.txt" CONTENT [[
+@cmake_copyright_comment@
+include(Platform/${PAL_PLATFORM_NAME}/platform_${PAL_PLATFORM_NAME_LOWERCASE}.cmake)
+]] @ONLY)
+    install(FILES "${target_install_source_dir}/CMakeLists.txt"
+        DESTINATION ${relative_target_source_dir}
+        COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
+    )
+
+    # 2. For this platform file, create a Platform/${PAL_PLATFORM_NAME}/platform_${PAL_PLATFORM_NAME_LOWERCASE}.cmake file 
+    #    that will include different configuration permutations (e.g. monolithic vs non-monolithic)
+    file(CONFIGURE OUTPUT "${target_install_source_dir}/Platform/${PAL_PLATFORM_NAME}/platform_${PAL_PLATFORM_NAME_LOWERCASE}.cmake" CONTENT [[
+@cmake_copyright_comment@
+if(LY_MONOLITHIC_GAME)
+    include(Platform/${PAL_PLATFORM_NAME}/Monolithic/permutation.cmake)
+else()
+    include(Platform/${PAL_PLATFORM_NAME}/Default/permutation.cmake)
+endif()
+]])
+    install(FILES "${target_install_source_dir}/Platform/${PAL_PLATFORM_NAME}/platform_${PAL_PLATFORM_NAME_LOWERCASE}.cmake"
+        DESTINATION ${relative_target_source_dir}/Platform/${PAL_PLATFORM_NAME}
+        COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
+    )
+
+    # 3. For this configuration permutation, generate a Platform/${PAL_PLATFORM_NAME}/${permutation}/permutation.cmake
+    #    that will declare the target and configure it
     ly_setup_subdirectory_create_alias("${absolute_target_source_dir}" CREATE_ALIASES_PLACEHOLDER)
     ly_setup_subdirectory_set_gem_variant_to_load("${absolute_target_source_dir}" GEM_VARIANT_TO_LOAD_PLACEHOLDER)
     ly_setup_subdirectory_enable_gems("${absolute_target_source_dir}" ENABLE_GEMS_PLACEHOLDER)
 
-    ly_file_read(${LY_ROOT_FOLDER}/cmake/install/Copyright.in cmake_copyright_comment)
-
-    # Initialize the target install source directory to path underneath the current binary directory
-    set(target_install_source_dir ${CMAKE_CURRENT_BINARY_DIR}/install/${relative_target_source_dir})
     # Write out all the aggregated ly_add_target function calls and the final ly_create_alias() calls to the target CMakeLists.txt
-    file(WRITE ${target_install_source_dir}/CMakeLists.txt
+    file(WRITE "${target_install_source_dir}/Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}/permutation.cmake"
         "${cmake_copyright_comment}"
         "${all_configured_targets}"
         "\n"
@@ -316,9 +348,8 @@ function(ly_setup_subdirectory absolute_target_source_dir)
         "${GEM_VARIANT_TO_LOAD_PLACEHOLDER}"
         "${ENABLE_GEMS_PLACEHOLDER}"
     )
-
-    install(FILES "${target_install_source_dir}/CMakeLists.txt"
-        DESTINATION ${relative_target_source_dir}
+    install(FILES "${target_install_source_dir}/Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}/permutation.cmake"
+        DESTINATION ${relative_target_source_dir}//Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}
         COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
     )
 
@@ -362,10 +393,10 @@ function(ly_setup_cmake_install)
     # Inject code that will generate each ConfigurationType_<CONFIG>.cmake file
     set(install_configuration_type_template [=[
         configure_file(@LY_ROOT_FOLDER@/cmake/install/ConfigurationType_config.cmake.in
-            ${CMAKE_INSTALL_PREFIX}/cmake/ConfigurationTypes_${CMAKE_INSTALL_CONFIG_NAME}.cmake
+            ${CMAKE_INSTALL_PREFIX}/cmake/Platform/@PAL_PLATFORM_NAME@/@LY_BUILD_PERMUTATION@/ConfigurationTypes_${CMAKE_INSTALL_CONFIG_NAME}.cmake
             @ONLY
         )
-        message(STATUS "Generated ${CMAKE_INSTALL_PREFIX}/cmake/ConfigurationTypes_${CMAKE_INSTALL_CONFIG_NAME}.cmake")
+        message(STATUS "Generated ${CMAKE_INSTALL_PREFIX}/cmake/Platform/@PAL_PLATFORM_NAME@/@LY_BUILD_PERMUTATION@/ConfigurationTypes_${CMAKE_INSTALL_CONFIG_NAME}.cmake")
     ]=])
     string(CONFIGURE "${install_configuration_type_template}" install_configuration_type @ONLY)
     install(CODE "${install_configuration_type}"
@@ -493,6 +524,11 @@ endfunction()"
         endif()
 
         # runtime dependencies that need to be copied to the output
+        # Anywhere CMAKE_INSTALL_PREFIX is used, it has to be escaped so it is baked into the cmake_install.cmake script instead
+        # of baking the path. This is needed so `cmake --install --prefix <someprefix>` works regardless of the CMAKE_INSTALL_PREFIX
+        # used to generate the solution.
+        # CMAKE_INSTALL_PREFIX is still used when building the INSTALL target
+        set(install_output_folder "\${CMAKE_INSTALL_PREFIX}/${runtime_output_directory}/${PAL_PLATFORM_NAME}/$<CONFIG>/${LY_BUILD_PERMUTATION}")
         set(target_file_dir "${install_output_folder}/${target_runtime_output_subdirectory}")
         ly_get_runtime_dependencies(runtime_dependencies ${target})
         foreach(runtime_dependency ${runtime_dependencies})
diff --git a/cmake/Platform/Mac/Install_mac.cmake b/cmake/Platform/Mac/Install_mac.cmake
index f3c2b31b31..8f07b1bfde 100644
--- a/cmake/Platform/Mac/Install_mac.cmake
+++ b/cmake/Platform/Mac/Install_mac.cmake
@@ -54,19 +54,19 @@ function(ly_install_target_override)
     install(
         TARGETS ${ly_platform_install_target_TARGET}
         ARCHIVE
-            DESTINATION ${ly_platform_install_target_ARCHIVE_DIR}/${PAL_PLATFORM_NAME}/$<CONFIG>
+            DESTINATION ${ly_platform_install_target_ARCHIVE_DIR}
             COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
         LIBRARY
-            DESTINATION ${ly_platform_install_target_LIBRARY_DIR}/${PAL_PLATFORM_NAME}/$<CONFIG>/${ly_platform_install_target_LIBRARY_SUBDIR}
+            DESTINATION ${ly_platform_install_target_LIBRARY_DIR}/${ly_platform_install_target_LIBRARY_SUBDIR}
             COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
         RUNTIME
-            DESTINATION ${ly_platform_install_target_RUNTIME_DIR}/${PAL_PLATFORM_NAME}/$<CONFIG>/${ly_platform_install_target_RUNTIME_SUBDIR}
+            DESTINATION ${ly_platform_install_target_RUNTIME_DIR}/${ly_platform_install_target_RUNTIME_SUBDIR}
             COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
         BUNDLE
-            DESTINATION ${ly_platform_install_target_RUNTIME_DIR}/${PAL_PLATFORM_NAME}/$<CONFIG>/${ly_platform_install_target_RUNTIME_SUBDIR}
+            DESTINATION ${ly_platform_install_target_RUNTIME_DIR}/${ly_platform_install_target_RUNTIME_SUBDIR}
             COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
         RESOURCE
-            DESTINATION ${ly_platform_install_target_RUNTIME_DIR}/${PAL_PLATFORM_NAME}/$<CONFIG>/${ly_platform_install_target_RUNTIME_SUBDIR}/
+            DESTINATION ${ly_platform_install_target_RUNTIME_DIR}/${ly_platform_install_target_RUNTIME_SUBDIR}
             COMPONENT ${CMAKE_INSTALL_DEFAULT_COMPONENT_NAME}
     )
 
diff --git a/cmake/install/ConfigurationTypes.cmake b/cmake/install/ConfigurationTypes.cmake
index 709f3e71ab..ce0fbd7963 100644
--- a/cmake/install/ConfigurationTypes.cmake
+++ b/cmake/install/ConfigurationTypes.cmake
@@ -15,7 +15,16 @@ include_guard(GLOBAL)
 set(CMAKE_CONFIGURATION_TYPES "" CACHE STRING "" FORCE)
 
 # For the SDK case, we want to only define the confiuguration types that have been added to the SDK
-file(GLOB configuration_type_files "cmake/ConfigurationTypes_*.cmake")
+# We need to redeclare LY_BUILD_PERMUTATION because Configurations is one of the first things included by the
+# root CMakeLists.txt. Even LY_MONOLITHIC_GAME is declared after, but since is a passed cache variable, and
+# default is the same as undeclared, we can use it at this point.
+if(LY_MONOLITHIC_GAME)
+    set(LY_BUILD_PERMUTATION Monolithic)
+else()
+    set(LY_BUILD_PERMUTATION Default)
+endif()
+
+file(GLOB configuration_type_files "cmake/Platform/${PAL_PLATFORM_NAME}/${LY_BUILD_PERMUTATION}/ConfigurationTypes_*.cmake")
 foreach(configuration_type_file ${configuration_type_files})
     include(${configuration_type_file})
 endforeach()
diff --git a/cmake/install/InstalledTarget.in b/cmake/install/InstalledTarget.in
index 2095211bb2..5022a108e8 100644
--- a/cmake/install/InstalledTarget.in
+++ b/cmake/install/InstalledTarget.in
@@ -23,5 +23,5 @@ ly_add_target(
 
 set(configs @CMAKE_CONFIGURATION_TYPES@)
 foreach(config ${configs})
-    include("@NAME_PLACEHOLDER@_${config}.cmake" OPTIONAL)
+    include("Platform/@PAL_PLATFORM_NAME@/@LY_BUILD_PERMUTATION@/@NAME_PLACEHOLDER@_${config}.cmake" OPTIONAL)
 endforeach()