diff --git a/Code/Framework/AzToolsFramework/AzToolsFramework/UI/Prefab/PrefabIntegrationManager.cpp b/Code/Framework/AzToolsFramework/AzToolsFramework/UI/Prefab/PrefabIntegrationManager.cpp
index 526912cf29..0bb596d0f6 100644
--- a/Code/Framework/AzToolsFramework/AzToolsFramework/UI/Prefab/PrefabIntegrationManager.cpp
+++ b/Code/Framework/AzToolsFramework/AzToolsFramework/UI/Prefab/PrefabIntegrationManager.cpp
@@ -800,16 +800,14 @@ namespace AzToolsFramework
             }
             else
             {
-                QString cleanSaveAs(QDir::cleanPath(prefabPath));
+                AZ::IO::FixedMaxPath lexicallyNormalPath = AZ::IO::PathView(prefabPath.toUtf8().constData()).LexicallyNormal();
 
                 bool isPathSafeForAssets = false;
-                for (AZStd::string assetSafeFolder : assetSafeFolders)
+                for (AZ::IO::Path assetSafeFolder : assetSafeFolders)
                 {
-                    QString cleanAssetSafeFolder(QDir::cleanPath(assetSafeFolder.c_str()));
-                    // Compare using clean paths so slash direction does not matter.
-                    // Note that this comparison is case sensitive because some file systems
-                    // Open 3D Engine supports are case sensitive.
-                    if (cleanSaveAs.startsWith(cleanAssetSafeFolder))
+                    // Check if the prefabPath is relative to the safe asset directory.
+                    // The Path classes are being used to make this check case insensitive.
+                    if (lexicallyNormalPath.IsRelativeTo(assetSafeFolder))
                     {
                         isPathSafeForAssets = true;
                         break;